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. 2011 Dec 12;80(1):139–152. doi: 10.3797/scipharm.1110-13

Tab. 1.

Name, chemical structure and chemical name of SP, MH and 3 impurities (Sitagliptin impurity, Metformin impurity-1 and Metformin impurity-2)

No. Name Structure IUPAC Name
1 Sitagliptin phosphate graphic file with name scipharm-2012-80-139f3.jpg (3R)-3-Amino-1-[3-(trifluoro- methyl)-5,6-dihydro[1,2,4]- triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate
2 Metformin hydrochloride graphic file with name scipharm-2012-80-139f4.jpg 3-(Diaminomethylidene)-1,1- dimethylguanidine hydrochloride
3 Sitagliptin impurity graphic file with name scipharm-2012-80-139f5.jpg N-[(2R)-4-Oxo-4-[3-(trifluoro- methyl)-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]acetamide
4 Metformin impurity-1 graphic file with name scipharm-2012-80-139f6.jpg 1-(Diaminomethylidene)-3- methylguanidine hydrochloride
5 Metformin impurity-2 graphic file with name scipharm-2012-80-139f7.jpg 1,3,5-Triazine-2,4,6-triamine