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mTOR complexes. mTOR is composed of two distinct complexes, mTORC1 and mTORC2. TORC1 is composed of mLST8, RAPTOR, DEPTOR and PRAS40, while the mTORC2 complex is composed of mSIN1, mLST8, RICTOR and DEPTOR. mTORC1 signals to S6K1, 4EBP1 and IRS1, whereas mTORC2 activates AKT, SGK1 and PKCα.
