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. 2012 Jan 15;11(2):253–263. doi: 10.4161/cc.11.2.19006

Figure 11.

Figure 11

Kaplan-Meier analysis of NRF1 target genes in breast cancer metastasis. Note that the signature for NRF1 target genes predicts breast cancer cell metastasis, especially in ER-positive patients. Numbers of cases with annotation are shown. p-values are as indicated. Kaplan-Meier analysis was performed as we previously described in references 72 and 84. X-Tile software was employed to identify subpopulation cut-points to observe maximum survival differences between the high expression and low expression subpopulations. The Log-rank test was used to evaluate the significance of differences in survival curves for high vs. low signature-expressing populations.