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. Author manuscript; available in PMC: 2012 Mar 5.
Published in final edited form as: Neuroscientist. 2011 Dec;17(6):659–676. doi: 10.1177/1073858411386615

Figure 4.

Figure 4

Histopathologic sections of spinal cord from a myelin basic protein-induced experimental allergic encephalomyelitis rat transfused with rat AQP4-specific CSF rAb 10 (Bennett and others 2009). H & E = hematoxylin/eosin staining reveals perivascular vacuolization and mononuclear and polymorphonuclear infiltrates (arrowheads). LFB = Luxol fast blue/PAS staining demonstrates perivascular demyelination and PAS+ macrophages (asterisks). C9neo = perivascular deposition of C9neo indicates local complement activation (arrowheads). GFAP = glial fibrillary acidic protein reveals extensive perivascular astrocyte loss associated with demyelination (asterisk). hIgG, human IgG deposition surrounding regions of perivascular demyelination (arrowheads). APP = amyloid precursor protein staining shows axonal transections (arrowheads).