Table 1.
Disintegrin | Inhibition of cell adhesion T24 cellsa |
Inhibition of cell adhesion SK-Mel-28 cellsa |
---|---|---|
GST-r-Mojastin | 200 nM | 16 nM |
r-Mojastin 1 | NA | 95 nM |
Native mojastin | NA | 113 nM |
NA = No activity.
Commercial echistatin used as positive control at 1.8 µM completely inhibited SK-MEL-28 and T24 cells adhesion to fibronectin.
The results are expressed as IC50