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Regulation of FBXL5 is dependent on assembly of diiron center within hemerythrin domain. Eight hours after transfection, HEK 293T cells were treated with either 100 μm DFO or 100 μm FAC for 16 h, and FBXL5 accumulation was assessed by immunoblot analysis. A, analysis of mutations to residues comprising the primary iron coordination shell. B, analysis of FBXL5 Glu-58 mutations.
