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Mitochondrial GPx4 is the major variant of GPx4 in the retina. A, SOD1, a cytosolic antioxidant enzymes was expressed more dominantly in OS than in IS. B, SOD2, a mitochondrial antioxidant enzyme was expressed in IS, not in OS. C–E, GPx4 and prohibitin, a mitochondrial marker, co-localized in the retina. F, in contrast, in RPE GPx4 and prohibitin did not co-localize. Scale bar, 50 μm.
