FIGURE 6.

TUNEL-positive cells and nuclear translocation of AIF in photoreceptor cells of the CKO mice. A–C, significant number of TUNEL-positive photoreceptor cells were observed in the CKO mouse retina at P17, but not in the control mouse retina. The TUNEL-positive cells appeared after P12. D–G, nuclear translocation of AIF was observed in photoreceptor cells of the CKO mice at P15, but not in the control mice (mean ± S.E.; n = 4; ns, not significant; ***, p < 0.001 by two-tailed t test for CKO versus control mice). Scale bar, 50 μm (B) and 10 μm (G).