FIGURE 7.
The growth factor Bmp7 is specifically induced by acute hepatic Hnf4a disruption. qRT-PCR analysis of livers from Hnf4aF/F;AlbERT2cre mice (n = 3) 9 days after tamoxifen treatment. A, gene expression analysis of major growth factors involved in liver regeneration expressed as relative value normalized to actin expression. -Fold change from Hnf4aF/F + tamoxifen is indicated for statistically significant changes (*, p < 0.05; **, p < 0.005). B, gene expression analysis of Bmp-related family members expressed as relative value normalized to actin expression. Statistically significant changes from Hnf4aF/F + tamoxifen mice as determined by one-way ANOVA are indicated (*, p < 0.05; **, p < 0.005). ns, not significant; Error bars, S.D.