TABLE 2.

Gene network analysis

Microarray results were processed through Ingenuity Pathway Analysis software to identify networks of genes most significantly affected by the phenotype and assigned a score based on the degree of relevance of the network to the genes in the data set. Networks with a score higher than 30 were considered highly relevant.

	Score
Up-regulated in bothHnf4aF/F;AlbERT2cre + tamoxifen and Alb-Hnf4a−/−
Cellular function and maintenance, dermatological diseases and conditions, genetic disorder	38
Antimicrobial response, inflammatory response, dermatological diseases and conditions	36
Cellular development, cell cycle, cellular growth and proliferation	32
Down-regulated in bothHnf4aF/F;AlbERT2cre + tamoxifen and Alb-Hnf4a−/−
Lipid metabolism, small molecule biochemistry, vitamin and mineral metabolism	48
Tumor morphology, inflammatory response, cell cycle	32
Lipid metabolism, molecular transport, small molecule biochemistry	32
Up-regulated inHnf4aF/F;AlbERT2cre + tamoxifen
Dermatological diseases and conditions, genetic disorder, antimicrobial response	34
Cell death, cellular development, cellular growth and proliferation	34
Skeletal and muscular system development and function, cellular growth and proliferation, cellular movement	32
Nervous system development and function, organ morphology, inflammatory disease	32
Up-regulated inAlb-Hnf4a−/−
Antimicrobial response, inflammatory response, dermatological diseases and conditions	34
Cellular movement, immune cell trafficking, cell-to-cell signaling and interaction	34
Small molecular biochemistry, organ development, reproductive system development and function	32
Cancer, reproductive system disease, cellular development	30