TABLE 3.

Changes in gene expression after 9 days of Hnf4a knockout

Data shown as -fold change over control Hnf4a^F/F mice. Significant differences from control as determined by one-way ANOVA are indicated.

	Control, Hnf4aF/F;AlbERT2cre	Tamoxifen (9-day)
		Hnf4aF/F	Hnf4aF/F;AlbERT2cre
Ccna2	1.01 ± 0.21	1.20 ± 0.55	4.55 ± 0.34a
Ccnb1	1.01 ± 0.15	2.15 ± 2.55	19.0 ± 1.991a
Ccnd1	1.23 ± 0.75	1.67 ± 0.84	22.75 ± 9.47b
Ccnd2	1.02 ± 0.28	0.68 ± 0.16	0.95 ± 0.13
Ccnd3	1.05 ± 0.41	1.11 ± 0.10	1.61 ± 0.70
Ccne2	1.02 ± 0.25	0.69 ± 0.09	2.72 ± 1.97b
Cdk1	1.12 ± 0.26	2.62 ± 1.31	16.79 ± 7.66b
Cdk2	1.02 ± 0.23	1.14 ± 0.48	2.06 ± 0.88
Cdk4	1.03 ± 0.29	0.88 ± 0.11	1.33 ± 0.15
Cdk6	1.00 ± 0.01	0.64 ± 0.08**	0.47 ± 0.09a
p53	1.62 ± 0.70	0.44 ± 0.06	1.68 ± 1.78
p63	1.12 ± 0.64	0.52 ± 0.14	0.58 ± 0.22
Perp	1.04 ± 0.34	1.03 ± 0.01	0.07 ± 0.02c
Prom1	1.03 ± 0.29	0.81 ± 0.13	71.8 ± 32.4b
Pcna	1.00 ± 0.05	0.93 ± 0.07	2.61 ± 0.96b
cMyc	1.02 ± 0.26	1.46 ± 1.05	5.85 ± 0.28c
p21	1.17 ± 0.83	2.16 ± 0.42	18.5 ± 1.37a
p27	1.01 ± 0.15	1.37 ± 0.64	0.56 ± 0.14b
Xiap	1.05 ± 0.37	0.37 ± 0.02b	0.20 ± 0.02c
cIap1	1.00 ± 0.09	1.22 ± 0.09	1.29 ± 0.33
cIap2	1.01 ± 0.18	1.19 ± 0.20	1.86 ± 1.27
Puma	1.01 ± 0.19	0.87 ± 0.22	0.85 ± 0.32
Bcl2	1.02 ± 0.24	0.76 ± 0.32	0.88 ± 0.33
Bcl-lx	1.03 ± 0.31	1.51 ± 0.31	1.66 ± 0.98

^a p < 0.0005.

^b p < 0.05.

^c p < 0.005.