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. 2012 Jan 17;287(10):7766–7779. doi: 10.1074/jbc.M111.290718

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — The translocation of DFF40/CAD from the cytosolic to the chromatin-enriched fraction is due to a preferential processing of ICAD_L/S in the cytosol. SK-N-AS (SK) and SH-SY5Y (SH) cells were treated (+) or not (−) with 1 μm STP for 6 h. Then cells were fractionated to obtain the cytosolic (C), the nucleoplasmic (N1), and the chromatin-enriched (N2) fractions, and caspase-3 and ICAD cleavage were analyzed by Western blot. PKM2 and topoisomerase I (TOPO I) were run as cytosolic and nuclear protein markers, respectively.