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Proposed model of FN phosphorylation of FGFR1 and downstream signaling. FN binds and activates β1 integrin. Activated β1 integrin signals to Src through an actin-dependent process to culminate in FGFR1 phosphorylation. The key residues that are sequentially phosphorylated on FGFR1 by this signaling cascade include tyrosine 653/654 and tyrosine 766. Phosphorylation of these residues leads to preferential downstream signaling activation of AKT, Rac1, and endothelial cell chemotaxis.
