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Wi-Phy (DrCBDmon-D207H/Y263F) structure. A, crystallographic packing of Wi-Phy occurs around a 2-fold symmetry axis distinct from the biological dimer interface. B, His-207 is positioned similarly in the Wi-Phy (buff) and H:Y263 (not shown) structures, with additional nearby waters (red spheres with 2Fo − Fc density contoured at 1σ). The C21 methyl group was modeled in the up and down alternative conformations. See supplemental Fig. 2 for embedded three-dimensional content.
