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Model of kinetic competition between protein synthesis and co-translational protein targeting. The ribosome-nascent chain complex can be targeted by the SRP pathway through three major steps, cargo binding (k1 and k−1), SRP-SR assembly (k2), and cargo unloading (k3) within a limited time window, which is dictated by the rate of translation elongation (kT) and the critical nascent chain length beyond which the SRP loses targeting competence.
