FIGURE 1.

Theoretical model of the purine salvage pathway of L. donovani. The purine salvage and interconversion enzymes predicted to be present in the L. donovani purine salvage pathway are depicted. 1, nucleoside hydrolase; 2, adenine aminohydrolase; 3, guanine deaminase; 4, adenine phosphoribosyltransferase; 5, hypoxanthine-guanine phosphoribosyltransferase; 6, xanthine phosphoribosyltransferase; 7, adenosine kinase; 8, AMP deaminase; 9, inosine monophosphate dehydrogenase; 10, GMP synthetase; 11, GMP reductase; 12, adenylosuccinate synthetase; 13, adenylosuccinate lyase.