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. 2011 Dec 6;20(3):580–589. doi: 10.1038/mt.2011.264

Figure 6.

Figure 6

Analysis of fibrosis in GRMD canines treated with rAAV6-U7-ESE6/8. Myocardium was co-stained for dystrophin and collagen I. Representative slides are shown from GRMD canines treated with 1.4 × 1013 gc/kg of rAAV6-U7-ESE6/8 and euthanized 13 months later. An untreated GRMD is shown as control. Note that collagen content is high when dystrophin staining is low or absent. The white arrow depicts collagen staining in a blood vessel wall. Bar, 200 µm. AAV, adeno-associated virus; GRMD, golden retriever muscular dystrophy; rAAV6, recombinant AAV6.