Figure 7.

Cardiac MRI assessment of function. (a) Left ventricular myocardium in the short-axis view was divided into six equal segments with the first segment placed in the anterior region. (b) The slice analyzed was located in the mid-papillary region and (c) the average peak circumferential strain (Ecc) was measured in the treated and untreated GRMD canines. (d) Note that both segment 5 and average Ecc are significant if the animal with the lowest dystrophin expression is removed from analysis. *P < 0.05. Error bars represent standard deviations. GRMD, golden retriever muscular dystrophy; MRI, magnetic resonance imaging.