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. 2011 Sep 27;20(3):669–678. doi: 10.1038/mt.2011.188

Figure 3.

Figure 3

Immunization with pConNS3/NS4A induces NS3-specific T cells able to produce numerous cytokines. PBMCs were stimulated with HCV NS3 peptides, overlapping by eight amino acids and spanning the entire length of the NS3 protein. PBMCs were stained intracellularly for IFN-γ, IL-2, and TNF-α ~2 months following the last immunization. (a) Average NS3-specific CD8+ T cell responses for each group. (b) Average NS3-specific CD4+ T cell responses for each group. Values are represented as mean + SEM, n = 5 per group. Significance was determined by Student's t-test (*P < 0.05, **P < 0.005, and ***P < 0.0005). HCV, hepatitis C virus; PBMC, peripheral blood mononuclear cell.