Table 1.
Clinical characteristics and their outcome association (EFS)
| Entire cohort |
MLL-AFF1 patients |
|||||||
|---|---|---|---|---|---|---|---|---|
| Value* | HR (SE)† | 5-y EFS (SE)‡ | P§ | Value* | HR (SE)† | 5-y EFS (SE)‡ | P§ | |
| Overall | ||||||||
| Total | 97 (100) | 0.41 (.05) | 48 (100) | 0.36 (.07) | ||||
| Age | .009 | .002 | ||||||
| ≤ 90 days | 24 (25) | 2.13 (.62) | .19 (.09) | 12 (25) | 3.25 (1.30) | 0 (NA) | ||
| > 90 days | 73 (75) | 1 | .48 (.06) | 36 (75) | 1 | .47 (.08) | ||
| Sex | .745 | .099 | ||||||
| Male | 54 (56) | 1.09 (.30) | .40 (.07) | 26 (54) | 1.82 (.68) | .28 (.09) | ||
| Female | 43 (44) | 1 | .42 (.08) | 22 (46) | 1 | .45 (.11) | ||
| WBC | .006 | .228 | ||||||
| ≥ 50 × 103/μL | 83 (86) | 5.70 (4.11) | .35 (.05) | 43 (91) | 3.20 (3.26) | .33 (.07) | ||
| < 50 × 103/μL | 13 (14) | 1 | .84 (.10) | 4 (9) | 1 | .75 (.22) | ||
| MLL status | .008 | |||||||
| Rearranged | 80 (82) | 3.23 (1.52) | .35 (.05) | 48 (100) | .36 (.07) | |||
| Germline | 17 (18) | 1 | .69 (.12) | 0 (0) | ||||
NA indicates not applicable.
*
Values are number and percentage of infants in parentheses.
†
HR is relative to the reference category (with HR = 1). SE indicates the standard error for each HR.
‡
Five-year EFS survival probability and SE.
§
P value of log-rank test.