Table 4.

Statistical significance of association of FVIII SNPs with the FVIII-VWF ratio for EA subjects

SNP	ABO adjusted	P (men, N = 3774)*	P (women, N = 4282)†
RS4898352	No	5.2 × 10−6	3.1 × 10−6
	Yes	2.8 × 10−6	4.6 × 10−6
RS5987077	No	1.2 × 10−5	5.6 × 10−6
	Yes	6.1 × 10−6	7.2 × 10−6
RS1470586	No	1.2 × 10−6	8.2 × 10−6
	Yes	8.5 × 10−7	1.3 × 10−5
RS6643622	No	4.7 × 10−5	1.1 × 10−5
	Yes	2.3 × 10−5	1.7 × 10−5
RS5945122‡	No	2.1 × 10−4	4.9 × 10−4
	Yes	3.8 × 10−4	5 × 10−4
RS5945258‡	No	1.7 × 10−4	5.6 × 10−4
	Yes	2.9 × 10−4	5.7 × 10−4
RS6643714‡	No	2.2 × 10−7	8.9 × 10−4
	Yes	1.5 × 10−7	1 × 10−4
RS7061362‡	No	>2 × 10−4	5.1 × 10−4
	Yes	3.7 × 10−4	5.1 × 10−4

Models are adjusted for age, BMI, ever smoking, diabetes, and hypertension (1 subject with outlier was not included from these models).

SNP indicates single nucleotide polymorphism; and EA, Americans of European descent.

^*There were 37 men were missing information on at least 1 of the predictors and were excluded from these models.

^†There were 27 women were missing information on at least 1 of the predictors and were excluded from these models.

^‡These SNPs were associated with FVIII activity in EA males as individual and in haplotypes.