Table 6.

Difference (and P value) in adjusted mean FVIII activity (%) by copy numbers of the haplotype and by ABO adjustment for EA men (N = 3671)

Haplotype	ABO adjusted	P	Difference
Block 1*
AT	No	6 × 10−4	3.74
	Yes	2 × 10−4	3.89
TC	No	7.7 × 10−3	−3.20
	Yes	7.3 × 10−3	−3.05
AC	No	8 × 10−2	−2.95
	Yes	2.9 × 10−2	−3.50
Block 2*
TACCAC	No	9.5 × 10−3	2.96
	Yes	1.2 × 10−2	2.71
GCTTTT	No	1.5 × 10−3	−4.71
	Yes	2 × 10−4†	−5.24
GACCTT	No	7.9 × 10−1	−0.50
	Yes	9.5 × 10−1	0.12
GACCAC	No	9.2 × 10−1	0.25
	Yes	6.5 × 10−1	1.11
GACCTC	No	9.8 × 10−1	0.07
	Yes	8.2 × 10−1	0.79

EA indicates Americans of European descent.

^*Adjusted for age, BMI, diabetes, hypertension, and ever smoking.