Table 5.

Effect of familial risk, gender and their interaction on total cerebellar volume, gray matter volume and white matter volume adjusting for ICV and age.

	Table 5A–Analysis for full sample (N=131)			Table 5B–Analysis for sample with no SUD prior to MRI scan (N=107)
	Full sample N=131			Sample with no SUD N=107^a
	F value	d.f.	p value	F value	d.f.	p value
Total cerebellum
Risk	3.65	1, 57.33	0.061	6.03	1, 41.39	0.018
Gender	4.64	1, 124.96	0.033	4.43	1, 101.94	0.038
RiskXGender	<1	1, 123.75	NS	<1	1, 101.28	NS
ICV	23.33	1, 118.70	<0.001	25.17	1, 92.49	<0.001
Age	2.21	1, 99.91	0.14	1.59	1, 73.08	NS
Gray matter
Risk	3.81	1, 62.05	0.056	4.88	1, 53.34	0.031
Gender	11.02	1, 124.65	0.001	10.32	1, 101.98	0.002
RiskXGender	1.12	1, 124.65	NS	<1	1, 100.73	NS
ICV	12.49	1, 124.74	0.001	12.32	1, 97.07	0.001
Age	<1	1, 100.97	NS	<1	1, 82.90	NS
White matter
Risk	<1	1, 125.0	NS	<1	1, 102	NS
Gender	1.89	1, 125.0	NS	1.83	1, 102	NS
RiskXGender	1.63	1, 125.0	NS	1.43	1, 102	NS
ICV	13.19	1, 125.0	<0.001	12.49	1, 102	0.001
Age	18.18	1, 125.0	<0.001	12.88	1, 102	0.001

A total of 131 cases had MRI scans. A total of 24 cases meeting criteria for alcohol or drug abuse or dependence prior to the MRI scan were removed from the analyses resulting in 107 cases with no known dependence. Analyses were completed for this sample and are displayed in Table 5B.