Table 3.
Adjusted-odds ratio (95% CI) for carotid atherosclerosis according to quartile of uric acid and metabolic syndrome by gender
| Quartile of serum uric acid | ||||
|---|---|---|---|---|
| Uric acid range Men (mg/dL) Women (mg/dL) |
UA-1 0.8-4.3 0.5-3.8 |
UA-2 4.4-5.5 3.9-4.7 |
UA-3 5.6-6.8 4.8-6.0 |
UA-4 6.9-16.1 6.1-15.4 |
| All subjects | ||||
| Men, N = 663 | 1 (reference) | 1.06 (0.63-1.76) | 1.75 (1.02-3.02) † | 2.01 (1.12-3.60) † |
| Women, N = 916 | 1 (reference) | 1.44 (0.94-2.21) | 1.29 (0.84-1.98) | 2.10 (1.30-3.39)§ |
| Subjects without metabolic syndrome (< 3 components of metabolic syndrome) | ||||
| Men, N = 483 | 1 (reference) | 0.92 (0.51-1.67) | 2.00 (1.03-3.87) † | 2.54 (1.21-5.34) ‡ |
| Women, N = 599 | 1 (reference) | 1.78 (1.06-3.00)† | 1.41 (0.83-2.40) | 2.54 (1.35-4.78)§ |
| Subjects with metabolic syndrome (≥3 components of metabolic syndrome) | ||||
| Men, N = 180 | 1 (reference) | 2.14 (0.67-6.81) | 1.55 (0.50-4.83) | 2.26 (0.72-7.10) |
| Women, N = 317 | 1 (reference) | 0.81 (0.36-1.79) | 1.12 (0.51-2.49) | 1.43 (0.62-3.27) |
CI, confidential interval. Adjusted for age, body mass index, smoking status, systolic blood pressure, diastolic blood pressure, antihypertensive medication, LDL-cholesterol, HDL-cholesterol, triglycerides, antilipidemic medication, fasting plasma glucose, antidiabetic medication, and history of cardiovascular disease. † P < 0.05; ‡ P < 0.01; § P < 0.005 vs. the first quartile (UA-1).