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Schematic illustration of the potential regulation by LMP-1 of a reciprocal regulatory loop involving BLIMP1α and MYC. LMP-1 might act initially to down-regulate BLIMP1α, which would release the BLIMP1α-mediated suppression of MYC. The up-regulation of MYC would lead to further suppression of BLIMP1α. Alternatively, LMP-1 might initially activate MYC expression.
