Table 1. Ex vivo chemosusceptibility values for quinolines.
Lines | CHLOROQUINE | MEFLOQUINE | QUININE | |||||||||
pressure | release | pressure | release | pressure | release | |||||||
IC50 | RI | IC50 | RI | IC50 | RI | IC50 | RI | IC50 | RI | IC50 | RI | |
Y-control | 0.11±0.014 | 1 | - | - | 0.1±0.03 | 1 | - | - | 1.02±0.3 | 1 | - | - |
Y-ART1 | 12±3.3* | 109 | nd | - | 10.3±1.7* | 103 | nd | - | 17.6±2.5* | 17 | nd | - |
Y-ART2 | 16.6±4.8* | 150 | nd | - | 7.6±2.3* | 76 | nd | - | nd | - | nd | - |
Y-ART3 | 9.5±1.8* | 86 | 0.09±0.02 | 0.8 | 11.1±2.6* | 111 | 0.03±0.004 | 0.3 | 24.3±5.5* | 24 | 0.36±0.03 | 0.35 |
Y-CQ1 | 14±2.4* | 127 | 0.073±0.03 | 0.66 | 12±2.9* | 120 | 0.025±0.002 | 0.25 | 39±11* | 39 | 0.51±0.05 | 0.5 |
Y-CQ2 | 16.8±1.8* | 152 | nd | - | 7.4±3.3* | 74 | nd | - | 27.7±17* | 27 | nd | - |