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. 2012 Mar 5;7(3):e32616. doi: 10.1371/journal.pone.0032616

Figure 5. Anti-amyloid activity of PLGA-curcumin nanoparticles.

Figure 5

A- Amyloid protein (Aβ) aggregates, B- Aβ and PLGA-curcumin nanoparticles after 12 hour co-incubation, C- Aβ and PLGA-curcumin nanoparticles after 24 hour co-incubation, D- Aβ and PLGA-curcumin nanoparticles after 48 hour co-incubation, E- Tet-1 conjugated PLGA-curcumin nanoparticles, F- Aβ and Tet-1 attached PLGA-curcumin nanoparticles after 12 hour co-incubation, G- Aβ and Tet-1 attached PLGA-curcumin nanoparticles after 24 hour co-incubation, H- Aβ and Tet-1 attached PLGA-curcumin nanoparticles after 48 hour co-incubation. It is observed that the nanoparticles are able to attach with the amyloid aggregates and help in disaggregation of the amyloid protein aggregates.