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. 2012 Mar 5;7(3):e32655. doi: 10.1371/journal.pone.0032655

Figure 2. Protein level of PV1 correlates with the number of structures capable of forming diaphragms in vivo.

Figure 2

A) Electron micrographs of capillary ECs of the kidneys (top panels) and lungs (middle and bottom panels) of WT, Cav1−/− and cavin-1−/− mice, as indicated. TEC and fenestrae are present in the kidneys of WT, Cav1−/− and cavin-1−/− mice (top panels). (Middle and bottom panels) Caveolae with stomatal diaphragms are present in the lungs of WT and absent in Cav1−/− and cavin-1−/− mice (middle panel). Insets in middle panels are a 2-fold magnification of the noted stretches of ECs. Bottom panels are a 3-fold magnification of ECs of Cav1−/− (left) and cavin-1−/− (right). Bars −200 nm. B) Morphometric analysis of the number of lung endothelial caveolae in WT and Cav1−/− mice demonstrating the absence of caveolae in the latter. C) Morphometric analysis of the numbers of kidney endothelial TEC, fenestrae and caveolae in WT and Cav1−/− mice.