Table 1. Laboratory characteristics of patients and controls.
| P1 (*1977) ♂ | P2 (*1952) ♂ | P3 (*1970) ♀ | P4 (*1944) ♂ | C1-4b | p valuesc | |
| Q705K/C10X | Q705K/C10X | Q705K/C10X | Q705K/C10Xa | |||
| CRP (mg/L)d | 129 | 67 | 23 | 82 | <10±0 | 0.0187 |
| normal range <10 | ||||||
| ESR (mm/h)d | 80 | 64 | 8 | 56 | 5.2±3.2 | 0.0239 |
| normal range 1–12 | ||||||
| WBC (×109/L)d | 23.3 | 11.6 | 12.2 | 15.7 | 5.6±0.8 | 0.0098 |
| normal range 3.5–8.8 | ||||||
| IL-1ß (pg/mL) | ||||||
| Plasma | 1.6 | 1.5 | - | 1.6 | 0.4±0.13 | <0.0001 |
| Supernatant | 99 | 137 | 69 | 55 | 28±11 | 0.0172 |
| LPS+ATP | 441 | 837 | 431 | 515 | 536±142 | nse |
| CD18 (MFI) | 239 | 329 | 210 | 198 | 257±123 | ns |
| CD11b high affinity (MFI) | 80 | 116 | 50 | 27 | 84±46 | ns |
| ROS (peak value, CPM) | ||||||
| fMet-Leu-Phe (×107) | 35.8 | - | 7.8 | 4.7 | 5.1±2.5 | ns |
| PMA (×108) | 4.7 | - | 2.4 | 4.8 | 3.3±1.3 | ns |
*
Year of birth.
a
Homozygote carrier of CARD-8 (C10X).
b
Data are given as mean ± SD,
c
Student's t-test was used to compare P1-P4 against their age and gender (♂, male; ♀, female) matched controls (C1–C4).
d
Measured at the accredited Clinical Chemistry Laboratory at Linköping University Hospital, Sweden.
e
ns = not statistically significant.