Table 1. Main characteristics of all studies included in the meta-analysis.
Study | Ethnicity | Genotyping method | Source of control | PHWE | Frequency of G allele | Cases/Controls | No. of cases | No. of controls | ||||
GG | GA | AA | GG | GA | AA | |||||||
Tanabe 2008a16 | Mixed | PCR-RFLP | HB | 0.19 | 0.001 | 59/148 | 23 | 27 | 9 | 32 | 65 | 51 |
Tanabe 2008b16 | Caucasian | PCR-RFLP | HB | 0.99 | 0.04 | 44/77 | 15 | 17 | 12 | 12 | 37 | 28 |
Abu 201117 | Mixed | allele-specific PCR | HB | 0.08 | 0.08 | 66/750 | 24 | 25 | 17 | 180 | 350 | 220 |
Chen 201118 | Chinese-Han | PCR-RFLP | HB and PB | 0.56 | 0.11 | 120/240 | 62 | 51 | 7 | 106 | 110 | 24 |
Li 200919 | Chinese-Han | PCR-RFLP | HB and PB | 0.94 | 0.12 | 186/338 | 96 | 82 | 8 | 161 | 145 | 32 |
Qi 200920 | Chinese-Han | PCR-RFLP | HB and PB | 0.75 | 0.55 | 215/380 | 102 | 98 | 15 | 182 | 160 | 38 |
Wang 2009a21 | Chinese* | PCR-RFLP | HB | 0.37 | 0.06 | 397/480 | 200 | 163 | 34 | 209 | 222 | 49 |
Wang 2009b21 | Chinese-Han | PCR-RFLP | HB | 0.53 | 0.06 | 217/200 | 125 | 76 | 16 | 94 | 89 | 17 |
Abbreviations: PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; PB, population-based; HB, hospital-based; PHWE, Hardy-Weinberg equilibrium of controls.
Included multiple ethnicities in China.