Table 2. Proliferative response in DP4-positive donors.
| DP4+ HBV vaccinated (SI) | DP4+ unvaccinated (SI) | |||||
| Positions | Donor 1 | Donor 2 | Donor 3 | Donor 4 | Donor 5 | Donor 6 |
| S109–121 | 1.1 | 0.9 | 0.8 | 1.0 | 0.8 | 0.9 |
| S181–192* | 7.2 | 3.6 | 0.8 | 3.1 | 0.8 | 1.1 |
| S256–268 | 2.4 | 1.4 | 0.4 | 3.1 | 0.7 | 1 |
| S326–338 | 1.4 | 2.3 | 0.5 | 3.5 | 1 | 1 |
| S347–358 | 1.2 | 2.2 | 0.6 | 1.1 | 1 | 0.9 |
| S352–364 | 1.2 | 3.1 | 0.7 | 1.6 | 1 | 0.7 |
*S181–S192 peptide was used as positive control.
The proliferation of CD4+ T cells in 4 HBV vaccinated and 2 unvaccinated HLA-DP4+ donors after in vitro stimulation with 5 newly identified HLA-DP4-restricted epitopes and one positive control peptide S181–S192. SI, stimulation index.