Table 4.
Added Value of Echocardiographic Score and NT-proBNP for Heart Failure Risk Prediction
| Statistic | BIC* | P (ΔBIC) | C | P (ΔC) | IDI (rIDI)† | ‡ NRI0 | P (NRI0) | ‡ NRIcat | P (NRIcat) |
|---|---|---|---|---|---|---|---|---|---|
| Main cohort (N=3752) | |||||||||
|
| |||||||||
| Health ABC HF Score | 4424.8 | Reference | 0.746 | Reference | Reference | Reference | Reference | Reference | Reference |
| Echocardiography added | 4381.8 | <0.001 | 0.777 | <0.001 | 0.044 (42.2%) | 31.8% | <0.001 | 10.6% | 0.007 |
| NT-proBNP added | 4360.7 | <0.001 | 0.773 | 0.004 | 0.045 (43.3%) | 31.7% | <0.001 | 11.3% | 0.007 |
| Echocardiography and NT-proBNP added | 4355.9 | <0.001 | 0.789 | <0.001 | 0.064 (61.7%) | 35.9% | <0.001 | 16.3% | <0.001 |
|
| |||||||||
| Quantitative LV subset (N=2538) | |||||||||
|
| |||||||||
| Health ABC HF Score | 2607.5 | Reference | 0.744 | Reference | Reference | Reference | Reference | Reference | Reference |
| Echocardiography added | 2532.2 | <0.001 | 0.798 | <0.001 | 0.056 (53.7%) | 39.7% | <0.001 | 18.8% | 0.001 |
| NT-proBNP added | 2570.1 | <0.001 | 0.774 | 0.014 | 0.033 (32.5%) | 26.6% | 0.001 | 12.1% | 0.024 |
| Echocardiography and NT-proBNP added | 2520.1 | <0.001 | 0.805 | <0.001 | 0.075 (72.8%) | 50.2% | <0.001 | 24.5% | <0.001 |
*
BIC: Bayesian information criterion.
†
IDI: Integrated discrimination improvement; rIDI expresses the relative improvement.
‡
NRI: Net reclassification improvement; NRI0 represents continuous NRI, which counts any movement of predicted probabilities; NRIcat is based on <5%, 5–10%, 10–20%, >20% categories and counts only movements that result in change in risk category.