Table 2.

Correlations between annual mean multiplicity of infection and the annual frequencies of mutant alleles and haplotypes

	Mean mspl MOI	p-value	Mean msp2 MOI	p-value
Gene, mutant codon
dhfr
51	−0.60	0.086	−0.80	0.010
59	−0.59	0.096	−0.76	0.016
108	−0.71	0.034	−0.76	0.018
dhps
437	−0.65	0.058	−0.85	0.004
540	−0.68	0.045	−0.88	0.002
pftndr1
86	−0.03	0.93	0.19	0.620
184	0.50	0.171	0.52	0.154
Gene, mutant haplotype
dhfr
Wildtype	0.72	0.028	0.79	0.011
Single	0.73	0.025	0.84	0.004
Double	0.45	0.224	0.63	0.067
Triple	−0.63	0.067	−0.82	0.007
dhps
Wildtype	0.68	0.045	0.82	0.002
Single	−0.19	0.63	0.03	0.93
Double	−0.68	0.042	−0.90	0.001
Combined dhfr-dhps
Wildtype	0.77	0.014	0.90	0.001
Single	0.75	0.020	0.91	<0.001
Double	0.65	0.060	0.82	0.007
Triple	0.74	0.021	0.93	<0.001
Quadruple	0.20	0.606	0.52	0.15
Quintuple	−0.72	0.030	−0.88	0.002
pftndr1
Wildtype	−0.32	0.406	−0.57	0.112
Single (NF)	0.42	0.265	0.52	0.154
Single (YY)	−0.03	0.932	0.193	0.62
Double (YF)	−0.20	0.604	−0.09	0.815

Significance of correlations determined by Spearman's rank correlation; significant correlations highlighted in bold. MOI: multiplicity of infection; msp1: merozoite surface protein 1; msp2: merozoite surface protein 2.