Skip to main content
. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Jan 10;1822(4):546–549. doi: 10.1016/j.bbadis.2012.01.004

Figure 2.

Figure 2

CA1 neuronal L-VSCC activity is reduced in 2xTg mice. A, Representative L-VSCC current traces (top 3 waveforms), and the average ensemble current (lowest trace) generated from 90-step WWwas elicited by stepping the patch membrane from −70 to +10 mV for 150 ms. Scale bars: 20pA/50ms. B, Mean ± SEM peak ensemble current density (pA/μm2) in each genotype group. C, Mean ± SEM unitary L-VSCC current amplitudes (i in pA) measured at different membrane potentials (Vm in mV). No genotype differences in slope conductance were observed. D, Mean ± SEM functional channel density in cell-attached patches from each genotype. *significant reduction relative to WT mice (p < 0.05, two-tailed unpaired T tests).