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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: J Immunol. 2012 Feb 15;188(6):2778–2793. doi: 10.4049/jimmunol.1101380

Figure 7. DEP Effects on M.tb-Induced Th1-Th2-Th3 Pathway-specific mRNA Expression.

Figure 7

Depicted on y-axes are statistically significant (p ≤ 0.01) mean fold changes (≥ 2-fold) ± standard error of the mean in mRNA expression levels of in vitro-stimulated PBMC from healthy subjects (n=11). Panel A shows the DEP-mediated (10 µg/mL) mRNA expression in PBMC relative to mRNA expression levels of unstimulated PBMC in culture medium (set as 0-line). Panel B shows mRNA expression levels from simultaneous DEP (10 µg/mL) and M.tb (MOI 10) stimulation of PBMC compared to mRNA expression levels from PBMC stimulated with M.tb alone (set as 0-line). Panel C shows the effect of DEP pre-stimulation on M.tb-induced mRNA expression. PBMC were pre-stimulated with DEP (10 µg/mL) for 20 hours and subsequently stimulated with M.tb at MOI 10 for an additional 24 hours. The mRNA expression levels of DEP pre-stimulated and subsequently M.tb-stimulated PBMC were compared to that of PBMC stimulated with M.tb alone (set as 0-line).