FIGURE 5.

Both HS10 and Ed are required for maximal Igκ expression during a T-cell-dependent Ab response. A, B, and C, production of anti-KLH and anti-TNP Abs after immunization of WT, HS10^−/− and Ed^−/− mice. The results show sera titers measured by ELISA assays 7 and 14 days after immunization. Sera titers were only at background levels at day 0 (± 0.2). P values compared to WT levels that were determined by one-way ANOVA using SPSS 11.5 software are shown at the top of panels A, B and C.