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. Author manuscript; available in PMC: 2012 Mar 6.
Published in final edited form as: Lancet. 2012 Jan 27;379(9818):823–832. doi: 10.1016/S0140-6736(11)61941-7

Table 4.

Algorithm genes

Gene name Chromosome Reference sequence Protein location Relevant biological functions and pathways Role in algorithm
BAG1 BCL2-associated athanogene 9p12 NM_004323 Cytoplasm Apoptosis; cell surface receptor linked signalling Prognosis
BRCA1 Breast cancer 1, early onset 17q21-q24 NM_007294 Nucleus Induction of apoptosis; protein ubiquitination; regulation of
G2/M transition DNA damage checkpoints; regulation of
DNA repair		 Prognosis
CDC6 Cell division cycle 6 homolog 17q21.3 NM_001254 Nucleus Regulation of transcription involved in G1/S phase of
mitotic cell cycle; regulation of cell proliferation		 Prognosis
CDK2AP1 Cyclin-dependent kinase 2
associated protein 1		 12q24 NM_004642 Nucleus Regulation of S phase of mitotic cell cycle; DNA-dependent
DNA replication		 Prognosis
ERBB3 V-erb-b2 erythroblastic leukemia
viral oncogene homolog 3		 12q13 NM_001982 Plasma membrane Regulation of cell adhesion; transmembrane receptor
protein tyrosine kinase signalling; regulation of
phosphoinositide 3-kinase cascade; regulation of cell
proliferation		 Prognosis
FUT3 Fucosyltransferase 3 19p13.3 NM_000149 Cytoplasm Carbohydrate metabolism; protein aminoacid glycosylation Prognosis
IL11 Interleukin 11 19q13.3-q13.4 NM_000641 Extracellular Regulation of cell proliferation; B-cell differentiation;
megakaryocyte differentiation; regulation of peptidyl-serine
phosphorylation; regulation of MAPKKK cascade		 Prognosis
LCK Lymphocyte-specific protein
tyrosine kinase		 1p34.3 NM_001042771 Cytoplasm Induction of apoptosis; activation of caspase activity;
regulation of T-cell receptor signalling; leucocyte migration		 Prognosis
RND3 Rho family GTPase 3 2q23.3 NM_005168 Cytoplasm Cell adhesion; small GTPase mediated signal transduction;
actin cytoskeleton organisation		 Prognosis
SH3BGR SH3 domain binding glutamic
acid-rich protein		 21q22.3 NM_007341 Cytoplasm Protein complex assembly Prognosis
WNT3A Wingless-type MMTV integration
site family, member 3A		 1q42 NM_033131 Extracellular Canonical Wnt receptor signalling; multicellular organismal
development; regulation of cell proliferation and
differentiation; regulation of catenin protein nuclear
translocation		 Prognosis
ESD Esterase D 13q14.1-q14.2 NM_001984 Cytoplasm Recycling of sialic acids; serine hydrolysis Reference
TBP TATA box binding protein 6q27 NM_003194 Nucleus Transcription initiation from RNA polymerase II promoter;
RNA elongation from RNA polymerase II promoter;
transcription from RNA polymerase III promoter		 Reference
YAP1 Yes-associated protein 1 11q13 NM_006106 Nucleus Hippo signalling cascade; regulation of transcription;
contact inhibition		 Reference