Table 4.

Factors associated with patient outcome

Characteristic	Univariate analysis
	LRFS		DRFS		DSS
	HR	p-value	HR	p-value	HR	p-value
Surgical margin (R1 vs. R0)	2.92	0.035	0.12	0.043	1.47	0.503
Gender (male vs. female)	0.46	0.084	0.53	0.40	1.36	0.592
Age (>60 vs ≤60 years)	0.32	0.011	0.66	0.59	0.98	0.502
Presentation status (primary vs. local recurrence)	1.4	0.43	1.13	0.87	0.97	0.968
Copy number alteration
3p14–21 loss	1.94	0.16	0.33	0.30	1.76	0.32
3q29 loss	1.57	0.32	0.00	<0.01	1.39	0.56
9p13 loss	2.35	0.037	1.28	0.76	0.77	0.70
10p 15 loss	1.05	0.92	0.48	0.48	1.55	0.47
11q23–24 loss	1.84	0.16	1.80	0.43	2.69	0.085
17p11 gain	2.08	0.13	1.06	0.94	1.19	0.77
17q21 loss	2.75	0.021	1.65	0.49	1.04	0.94
19q13 loss	2.86	0.013	1.51	0.57	7.36	0.0025
20q11 gain	0.97	0.96	1.40	0.68	0.60	0.51

DRFS, distant-recurrence–free survival; DSS, disease-specific survival; HR, hazard ratio; LRFS, local-recurrence–free survival.