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Molecular characteristics of DFSP in patients with ADA-SCID. A, Karyotyping from a lesion (ADA14) showing t(17;22)(q22;q13). B, FISH of a lesion (ADA16) revealing 2 fused red/green signals consistent with the presence of the COL1A1-PDGFB fusion. C, Sequence of the RT-PCR product from a lesion (ADA7) showing the junction of the COL1A1 and PDGFB transcripts.
