Table 2.
Right and left extralobar PA inner diameter (RPA and LPA, respectively) measured by microCT at a perfusion pressure of 17 mmHg and main PA (MPA) inner diameter computed from these by Murray’s Law. Distensibility (α) and compliance (C) for RPA, LPA and MPA over the pressure range 6.3 to 17.2 mmHg.
Col1a1+/+ | Col1a1R/R | ||||||
---|---|---|---|---|---|---|---|
Normoxia (n=3) | Hypoxia (n=5) | Recovery (n=5) | Normoxia (n=4) | Hypoxia (n=5) | Recovery (n=4) | ||
ID | RPA [mm] | 1.29±0.31 | 1.26±0.17 | 1.31±0.21 | 1.04±0.07 | 1.10±0.07 | 1.17±0.04 |
LPA [mm] | 0.92±0.16 | 0.90±0.11 | 0.94±0.15 | 0.85±0.05 | 0.80±0.09 | 0.86±0.04 | |
MPA [mm] | 1.43±0.32 | 1.39±0.18 | 1.46±0.23 | 1.20±0.08 | 1.23±0.09 | 1.31±0.05 | |
α | RPA [1/mmHg] | 0.030±0.008 | 0.020±0.001 | 0.030±0.010 | 0.020±0.004 | 0.020±0.005 | 0.025±0.004 |
LPA [1/mmHg] | 0.030±0.005 | 0.020±0.007 | 0.030±0.009 | 0.020±0.003 | 0.020±0.010 | 0.020±0.004 | |
MPA [1/mmHg] | 0.032±0.007 | 0.016±0.08 | 0.030±0.05 | 0.020±0.003 | 0.030±0.005 | 0.020±0.004 | |
C | RPA [mm2/mmHg] | 0.016±0.005 | 0.015±0.006 | 0.024±0.017 | 0.009±0.002 | 0.008±0.002 | 0.013±0.001 |
LPA [mm2/mmHg] | 0.008±0.002 | 0.007±0.002 | 0.012±0.008 | 0.006±0.002 | 0.004±0.002 | 0.007±0.001 | |
MPA [mm2/mmHg] | 0.022±0.01 | 0.011±0.007 | 0.016±0.003 | 0.012±0.0015 | 0.017±0.001 | 0.014±0.002 |