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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Curr Opin Cell Biol. 2011 Dec 22;24(1):100–106. doi: 10.1016/j.ceb.2011.11.011

Figure 1.

Figure 1

NPC architecture – structural and dynamic features. A) General structure of the NPC. An NPC sliced through its center is shown revealing the octameric symmetry of its major features. The ring stack in the center extends outwards into the nucleus and cytoplasm by means of filaments resulting in eight spokes transversing the nuclear membrane. There is possibly a slight shift between the upper and lower rings as shown in B. The FG nups, anchored in the center, form the permeability barrier. C) Nucleoporins display a wide range of turnover rates within the NPC ranging from seconds to tens of hours. Core components are generally more stably associated compared to the asymmetric nucleoporins. Nup98 (yellow), the nucleoporin with the most FG repeats, has a medium association time (hours), while gb210 (see text), although part of the luminal ring shows fast turnover at the minutes time scale. (Adapted from Grünwald et al. 2011, Nature)