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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2012 Jan 10;52(3):689–700. doi: 10.1016/j.yjmcc.2011.12.013

Figure 5. Quantification of cell proliferation, VIC density and SMA expression in mouse models of valve disease.

Figure 5

(A) The number of pHH3 positive nuclei/total nuclei in aortic valve leaflets was calculated for 3 independent sections of 3 hearts per genotype. (B) The total number of nuclei per μm2 of aortic valve leaflet area was calculated for 3 independent sections of 3 hearts per genotype. (C) The number of SMA positive cells/total nuclei in aortic valve leaflets was calculated for 3 independent sections of 3 hearts per genotype. Cohorts of oim and Postn mice and controls were evaluated at 4 months of age. Klotho null mice and WT littermates were evaluated at 6 weeks of age. Statistical significance was determined by paired student’s t-test. * is p≤0.05.