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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Allergy Clin Immunol. 2012 Jan 29;129(3):607–616. doi: 10.1016/j.jaci.2012.01.032

Figure 1.

Figure 1

Generation of the δRec-ΨJα TREC. The germ line configuration of the TCRA locus, with TCRD embedded, is shown at the top of the Figure, which also shows the points (gray dots) at which the DNA is cut to excise the TCRD locus in T lymphocyte progenitors destined to express the α and β TCRs. After excision, lower left, and ligation, lower right, of the δRec-ΨJα fragment to form a T cell receptor excision circle (TREC), PCR primers (horizontal arrows) can amplify a DNA junction fragment containing the joint.