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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: J Immunol. 2012 Feb 3;188(6):2583–2591. doi: 10.4049/jimmunol.1102715

Figure 6. Chronic shift lag increases tumor frequency and incidence in the lungs.

Figure 6

Lung tumor frequency (A) and percentage of animals with tumors (B) is increased in shifted animals. Animals displaying reentrainment during the repeated shifting schedule tended to have an increased tumor load compared to shifted animals displaying free-running activity rhythms (C; p = 0.07). Pictures of lungs with multiple tumor loci (circled) from representative animals in control (D, row 1) and shifted (C, row 2) groups. ***, p < 0.0001, significant difference between groups.