Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Cancer Prev Res (Phila). 2011 Dec 15;5(3):473–483. doi: 10.1158/1940-6207.CAPR-11-0318

Figure 6. Effect of didymin signaling pathways in neuroblastoma.

Figure 6

The novel flavonoid didymin inhibits N-Myc transcription. Didymin down-regulated PI3K, Akt, vimentin and up regulated RKIP. Didymin down regulated cyclin D1, CDK4 and importantly cyclin B1, which is down-stream effector of p53 mediated cell-cycle regulation. Didymin decreased the angiogenic marker CD31, proliferation marker ki67 and N-Myc in vivo as revealed by histopathological examination of resected tumors. Dotted arrows -Normal signal transduction, normal arrows - Up regulation of signaling protein due to didymin, T-shaped lines -Inhibitory effect of didymin.