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. Author manuscript; available in PMC: 2013 Apr 27.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 9;37(1):194–202. doi: 10.1016/j.pnpbp.2012.01.003

Figure 2. Behavioral effects of 20-min acute exposure to mescaline and phencyclidine (PCP) on zebrafish rotational behavior in the open field test (Experiment 2).

Figure 2

Rotation data represent the number of total (left + right) rotations and the percentage of animals per group displaying `high rotation' behaviors (5 or more `full' rotations) during the 6-min test (n = 13–14 per group). ANOVA results show a significant drug effect on the number of total rotation (F(2,38) = 8.6, p<0.001) and the percentage of animals showing `high rotation' phenotype (F(2,38) = 13.2, p<0.001). Representative traces showing rotation behavior in PCP-treated fish (vs. control) were generated by Noldus Ethovision XT7 software using the top view video-recording (only a 1-min segment of a 6-min test if presented, for clarity). In all experiments, the traces were examined for each experimental cohort, rated from 1 to n (based on similarity to each other), and the middle trace was selected as representative, to illustrate the patterns of zebrafish locomotion (see Table 1 for details of other behaviors observed in the open field test). ***P<0.001 vs. control, &P<0.05 vs. mescaline group; post-hoc Tukey test for significant ANOVA data.