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Skin retention of KP after 24 h in the different skin layers. The study was performed in vitro using Franz diffusion cells on dermatomed human skin. The skin biopsies were collected and processed further to detect the amount of KP permeated in each layers of skin. The data represent the amount of KP per g of skin for different formulations of KP. Data represent mean ± SEM, n=6; significance OA modified NPS against OA unmodified, physical mixture and solution, **p < 0.001.
