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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: J Immunol. 2012 Feb 13;188(6):2894–2904. doi: 10.4049/jimmunol.1101391

Figure 9.

Figure 9

Effect of neonatal RV infection on IL-4R null mice. BALB/c-Il4ratm1Sz/J mice were inoculated with sham or RV at day 7 of life and airway tissues examined 28 days post-infection. Unlike RV-infected wild-type BALB/c mice (see Figure 6), IL-4R null mice showed no PAS-positive cells in large, medium or small airways (A–C). These images are representative of two individual experiments of three mice per group. D. Lung Gob5, MUC5AC, MUC5B and IL-13 mRNA expression was measured by qPCR. Unlike wild-type mice (see Figure 7), RV-infected IL-4R null mice failed to show an increase in mucus or IL-13 expression. N = 3–5 animals per group.