The ligand RMSD and the retrieval rank difference by Pocket-Surfer and Patch-Surfer. The x-axis shows the average RMSD between the ligand molecule of each query pocket to the other ligands of the same type in the dataset. The y-axis shows the difference in the retrieval rank of each ligand of the same type by Pocket-Surfer and by Patch-Surfer (rank by Pocket-Surfer – rank by Patch-Surfer). A, B, results on the Kahraman dataset using pocket shape information with and without using pocket size information, respectively. C and D are results on the Huang dataset. Retrieval was performed using pocket shape information C, without and D, with pocket size information.