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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):446–453. doi: 10.1097/MPG.0b013e31823d34c3

Figure 2.

Figure 2

Cl− transport in intestinal epithelial cells. At the basolateral membrane, Cl− enters the cell from blood across the Na+-K+-2Cl cotransporter. Na is expelled by the Na pump, and K leaves via a K channel. Na is shown crossing the cell layer via a paracellular pathway, but Na channels also exist (not shown). Both cystic fibrosis transmembrane regulator (CFTR) and ClC-2 Cl− channels are present on the apical membrane and can allow Cl− to exit the cell. Reproduced from ref. 122, Cuppoletti J, Malinowska DH, Tewari KP, et al. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol 2004;287:C1173–83.